Table 4 Different cutoff points of the ACAChE score to predict poor anticoagulant control on warfarin (TTR < 65%)
|
ACAChE score ≥ 1 TTR < 65% |
ACAChE score ≥ 2 TTR < 65% |
ACAChE score ≥ 3 TTR < 65% |
ACAChE score ≥ 4 TTR < 65% |
ACAChE score ≥ 5 TTR < 65% |
ACAChE score ≥ 6 TTR < 65% |
ACAChE score ≥ 7 TTR < 65% | |
|---|---|---|---|---|---|---|---|
| Sensitivity |
97.3 (95.8–98.4) |
95.8 (93.9–97.2) |
68.1 (64.4–71.7) |
43.8 (39.9–47.8) |
35 (31.3–38.9) |
19.5 (16.5–22.8) |
13.8 (11.2–16.7) |
| Specificity |
2.65 (0.98–5.69) |
3.54 (1.54–6.86) |
47.3 (40.7–54.1) |
75.2 (69.1–80.7) |
83.2 (77.7–87.8) |
93.4 (89.3–96.2) |
95.1 (91.5–97.5) |
| Likelihood ratio (+) |
1.00 (0.975–1.03) |
0.993 (0.964–1.02) |
1.29 (1.13–1.48) |
1.77 (1.39–2.26) |
2.08 (1.53–2.83) |
2.93 (1.75–4.9) |
2.84 (1.55–5.21) |
| Likelihood ratio (−) |
1.01 (0.401–2.52) |
1.2 (0.552–2.6) |
0.673 (0.563–0.804) |
0.747 (0.675–0.827) |
0.781 (0.72–0.848) |
0.863 (0.819–0.908) |
0.906 (0.868–0.946) |
| Odd ratio |
0.995 (0.399–2.48) |
0.829 (0.378–1.82) |
1.92 (1.41–2.62) |
2.37 (1.69–3.32) |
2.66 (1.82–3.91) |
3.4 (1.96–5.91) |
3.13 (1.66–5.92) |
| Positive predictive value |
73.8 (70.7–76.8) |
73.7 (70.5–76.6) |
78.5 (74.8–81.8) |
83.3 (78.8–87.1) |
85.4 (80.6–89.5) |
89.2 (82.8–93.8) |
88.9 (81–94.3) |
| Negative predictive value |
26.1 (10.2–48.4) |
22.9 (10.4–40.1) |
34.5 (29.2–40.1) |
32.2 (28.2–36.4) |
31.2 (27.5–35.1) |
29.1 (25.9–32.6) |
28.1 (25–31.5) |
| Accuracy |
72.54 (69.43–75.49) |
71.61 (68.47–74.6) |
62.69 (59.36–65.93) |
52.03 (48.63–55.41) |
47.62 (47.71–54.49) |
38.82 (35.55–42.16) |
35.11 (31.92–38.4) |
| p value | 0.991 | 0.647 | < 0.001 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |